منابع مشابه
Membrane proteins stick around
You wouldn't call it a long-term relationship, but the interaction between proteins and certain membrane lipids is not just a one-millisecond stand. As Hammond et al. discovered, the proteins remain attached to the lipids longer than researchers expected. The fi ndings explain how these lipids localize their effects. By temporarily hooking up with various proteins, inositol lipids in the plasma...
متن کاملForcing cells to stick around
eukocytes have a better chance of sticking to neighboring cells with the right ligands if they rotate on their way by, based on results from Dwir et al. (page 649). Flowing leukocytes are captured via L-selectin interactions with carbohydrate ligands on vessel walls and subsets of other leukocytes. L-selectin is an unusual adhesive molecule—shear stress improves its adherance to ligands, wherea...
متن کاملMaking Dictyostelium stick
euronal growth cones have detergent-resistant membranes (DRMs), specialized cell membrane fractions enriched in GPI-anchored proteins and intracellular signaling molecules. But are the DRMs involved in regulating neurite outgrowth? Yes, say Nakai and Kamiguchi (page 1097), who developed a new technique for selectively disrupting DRMs, and used it to demonstrate the functional importance of thes...
متن کاملBeyond education and training: making change stick.
Medicine is in constant change, with new evidence continually replacing how we consider health and illness. In health care we are deluged with articles about change — how to accomplish it, how to measure it, how to sustain it. Patients have become more robust advocates. With the proliferation of new medications and data, both patients and clinicians must rely upon online information, as printed...
متن کاملEncoding New Episodes and Making Them Stick
How do we encode, store, and retrieve new episodic memories, and what are the computations performed by the hippocampus during this process? One system that has been used to model the brain basis of episodic memory in humans is the study of spatial navigation by path integration in rodents. Here I discuss three exciting new findings focused on encoding or replay of spatial sequences in the rat ...
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ژورنال
عنوان ژورنال: Science
سال: 2016
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.352.6284.425-f